期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 35, 期 3, 页码 444-453出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2013.01.010
关键词
Carbendazim; Kolaviron; Steroidogenesis; Apoptosis and Testes
资金
- John D. and Catherine T. MacArthur Foundation Fellowship (USA) endowment from the University of Ibadan, Nigeria
- INSA-JRD TATA Fellowship (India)
- Multidisciplinary Research Grants under the Staff Training and Research Capacity Building Programme of the John D. and Catherine T. MacArthur Foundation Grant (USA) endowment from the University of Ibadan, Nigeria
The study evaluated the protective role of kolaviron (an isolated biflavonoid from the seed of Garcinia kola) and vitamin E in carbendazim-induced reproductive dysfunction in male rats. Adult male Wistar rats were orally exposed to carbendazim (200 mg/kg) singly or in combination with kolaviron (100 and 200 mg/kg). Exposure to carbendazim significantly decreased the activities of superoxide dismutase and catalase but markedly increased sialic acid concentration and lipid peroxidation in the testes of rats. Western blot analysis revealed that carbendazim treatment decreased the expression of steroid acute regulatory (StAR) protein and androgen binding protein (ABP) with concomitant decrease in activities of steroidogenic enzymes. Germ cell apoptosis in carbendazim-treated rats was confirmed by TUNEL assay. However, pretreatment with kolaviron and vitamin E restored the testicular antioxidant status and steroidogenesis and decreased apoptotic nuclei to near control level in carbendazim-treated rats. Kolaviron may prove useful in combating carbendazim-induced reproductive toxicity. (c) 2013 Elsevier B.V. All rights reserved.
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