期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 36, 期 3, 页码 1141-1149出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2013.09.020
关键词
DEHP; Endocrine-disruptors; Estradiol; LH; Ovulatory-cycles; Progesterone
资金
- Universidad Complutense de Madrid [PR41/06-150053]
The patterns of growth of preovulatory follicles and corpora lutea, as well as plasma concentrations of estradiol, progesterone and LH were evaluated in sheep exposed to DEHP. There were not found effects on the preovulatory follicular dynamics nor on the ovulatory efficiency between DEHP-exposed and control sheep. However, plasma estradiol concentration was significantly higher in the ewes exposed to DEHP than in the control females (P <0.001). Afterwards, DEHP-exposed ewes had significantly higher plasma progesterone concentration from Day 2 of the luteal phase (P <0.05), although there were no differences between groups in the macro- and microscopic features of the corpora lutea. Analysis of mean basal concentrations of LH showed lower values in DEHP-exposed than in control sheep (0.3 +/- 01 ng/mL vs. 0.7 +/- 0.1; P <0.05). Moreover, the frequency of LH pulses was 0.3 pulses/4 h, with amplitude of 0.6 ng/mL, in the control group; on the other hand, the pulsatile secretion of LH in the DEHP-exposed group was undetectable during the period of sampling. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据