期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 34, 期 2, 页码 388-396出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2012.05.007
关键词
Herbicide; Histopathology; Immunohistochemistry; Lethal concentration; Teleost
资金
- FAPESP [Proc. 2009/04508-3]
- CNPq/INCT-TA [Proc. 573949/2008-5]
- CNPq
The aim of this study was to determine the acute toxicity of Roundup (R) Ready (RR) in Piaractus mesopotamicus, and evaluate the effects on the morphology of the gills and liver of exposed surviving fish. Fish were exposed to 3.0, 3.5, 4.0 and 4.5 mg L-1 of glyphosate, and the LC50;48 h was estimated at 3.74 +/- 0.2 mg L-1. Gill histopathology was rare, and the activity of Na+/K+-ATPase enzyme did not change, suggesting normal function. However, the damage to the liver was classified as moderate to severe. Cytoplasmic vacuolization, lipid accumulation, nuclear and cellular membrane alterations and glycogen depletion were found in the liver, suggesting a reduction in the liver function. The glyphosate in the RR formulation was classified as moderately toxic for P. mesopotamicus, and the severe damage in the liver may affect the detoxification and/or tissue repair process and contribute to fish death. (C) 2012 Elsevier B.V. All rights reserved.
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