期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 32, 期 2, 页码 136-145出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2011.04.004
关键词
Psidium guajava; Atopic dermatitis; TARC; Heme oxygenase-1
资金
- Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea [20090237]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [20090237] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Psidium guajava (P. guajava) is a food and medicinal plant with antioxidant, anti-inflammatory, and anti-allergic activities that support its traditional uses. The aim of this study was to determine the effects of P. guajava ethyl acetate extract (PGEA) on atopic dermatitis and to investigate the possible mechanisms by which PGEA inhibits cytokine-induced Th2 chemokine expression in HaCaT human keratinocyte cells. We found that PGEA suppressed the IFN-gamma/TNF-alpha-co-induced production of thymus and activation-regulated chemokine (TARC) protein and mRNA in HaCaT cells. Additionally, PGEA inhibited the TNF-alpha/IFN-gamma-co-induced activation of NF-kappa B and STAT1 and increased the expression of heme oxygenase-1 (HO-1) protein and mRNA. HO-1 inhibitor enhanced the suppressive effects of PGEA on TNF-alpha/IFN-gamma-co-induced TARC production and gene expression. Collectively, these data demonstrate that PGEA inhibits chemokine expression in keratinocytes by inducing HO-1 expression and it suggests a possible therapeutic application in atopic dermatitis and other inflammatory skin diseases. (C) 2011 Elsevier B.V. All rights reserved.
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