期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 31, 期 1, 页码 107-118出版社
ELSEVIER
DOI: 10.1016/j.etap.2010.09.011
关键词
Phosphate supplement; Arsenic transference; Arsenic toxicity; Oxidative stress; Hepatic mitochondrial toxicity; Hepatic injury
资金
- Department of Science and Technology, Government of West Bengal, India
The present study was aimed to test the hypothesis that inorganic phosphate may reduce arsenic toxicity by decreasing its intestinal transference. Co-administration of inorganic phosphate (6.56 M) and arsenic (6.07 mM) in the intestinal loops of rats, in situ, caused significant reduction of arsenic transference. Short-term arsenic exposure (3 mg/kg body weight/day for 30 days) caused liver damage evidenced by activities of liver enzymes and necroinflammatory changes. These effects of arsenic were coupled with enhanced mitochondrial swelling, inhibition of cytochrome c oxidase, Ca2+-ATPase, a decrease in mitochondrial calcium content, changes in indices of hepatic mitochondrial oxidative stress and iNOS expression. Arsenic also increased hepatic caspase 3 activity and DNA fragmentation. All these apoptosis-related molecular changes caused by arsenic could be alleviated by supplementation with inorganic phosphate, which likely suggests a protective role of phosphate against arsenic-induced hepatotoxic changes. (C) 2010 Elsevier B.V. All rights reserved.
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