期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 28, 期 1, 页码 37-41出版社
ELSEVIER
DOI: 10.1016/j.etap.2009.02.001
关键词
Glyphosate; Comet assay; Chromosome aberrations; Micronucleus; TBARs; SOD; Catalase
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)
- Secretaria de Ciencia y Tecnica, Universidad Nacional de Rio Cuarto, UNRC
It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42 +/- 1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p < 0.01) with glyphosate at a range concentration from 3.00 to 7.50 mM. In the chromosome aberrations (CA) test in human lymphocytes the herbicide (0.20-6.00 mM) showed no significant effects in comparison with the control group. In vivo, the micronucleus test (MNT) was evaluated in mice at three doses rendering statistical significant increases at 400 mg/kg (13.0 +/- 3.08 micronucleated erythrocytes/ 1000 cells, p < 0.01). In the present study glyphosate was genotoxic in the comet assay in Hep-2 cells and in the MNT test at 400 mg/kg in mice. Thiobarbituric acid reactive substances (TBARs) levels, superoxide dismutase (SOD) and catalase (CAT) activities were quantified in their organs. The results showed an increase in these enzyme activities. (C) 2009 Elsevier B.V. All rights reserved.
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