期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 32, 期 8, 页码 1842-1845出版社
WILEY-BLACKWELL
DOI: 10.1002/etc.2258
关键词
Toxicokinetic-toxicodynamic modeling; Glutathione S-transferase; Biomarker; Survival; Copepods
资金
- Research Council of Norway [196711/S40]
The practical usefulness of biomarkers is limited by the complexity of linking their responses to life-history traits of the organisms (e.g., survival, growth, reproduction) over time. Here the authors present a first attempt to model biomarker responses and survival over time simultaneously with a toxicokinetic-toxicodynamic approach. Even though more work is clearly needed, the present study provides a novel direction for interpreting biomarker responses and dynamically linking them to life-history traits. Environ Toxicol Chem 2013;32:1842-1845. (c) 2013 SETAC
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