期刊
JOURNAL OF RHEUMATOLOGY
卷 42, 期 3, 页码 363-371出版社
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.140382
关键词
OSTEOARTHRITIS; INNATE IMMUNITY; MACROPHAGES; COMPLEMENT
类别
资金
- US National Institutes of Health (NIH) [5T32AI007217-30]
- NIH/National Institute on Aging Grant [5P30 AG028716]
- NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant [P01 AR050245]
Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis remains poorly understood. OA is no longer considered a wear and tear condition but rather one driven by proteases where chronic low-grade inflammation may play a role in perpetuating proteolytic activity. While multiple factors are likely active in this process, recent evidence has implicated the innate immune system, the older or more primitive part of the body's immune defense mechanisms. The roles of some of the components of the innate immune system have been tested in OA models in vivo including the roles of synovial macrophages and the complement system. This review is a selective overview of a large and evolving field. Insights into these mechanisms might inform our ability to identify patient subsets and give hope for the advent of novel OA therapies.
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