期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 108, 期 -, 页码 33-41出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2014.12.001
关键词
Galectins; Angiogenesis; Pregnancy
资金
- Deutsche Forschungsgemeinschaft (DFG) [BL1115/2-1]
- Fritz Thyssen Stiftung [Az. 10.10.2.125]
- Charite
- Rachel Hirsch Habilitation fellowship
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina)
Members of the galectin family have been shown to exert several roles in the context of reproduction. They contribute to placentation, maternal immune regulation and facilitate angiogenesis encompassing decidualisation and placenta formation during pregnancy. In the context of neo-vascularisation, galectins have been shown to augment signalling pathways that lead to endothelial cell activation, cell proliferation, migration and tube formation in vitro in addition to angiogenesis in vivo. Angiogenesis during gestation ensures not only proper foetal growth and development, but also maternal health. Consequently, restriction of placental blood flow has major consequences for both foetus and mother, leading to pregnancy diseases. In this review we summarise both the established and the emerging roles of galectin in angiogenesis and discuss the possible implications during healthy and pathological gestation. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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