期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 48, 期 21, 页码 12912-12919出版社
AMER CHEMICAL SOC
DOI: 10.1021/es504263u
关键词
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资金
- National Institute of General Medical Sciences [U54 GM104942]
- National Institutes of Health [R01 HL095579, R01 ES022968, P30 GM103488, P20 RR016440, P30 RR032138/GM103488, S10 RR026378]
- Mary Babb Randolph Cancer Center
Epidemiological studies suggest that living near mountaintop coal mining (MTM) activities is one of the contributing factors for high lung cancer incidence. The purpose of this study was to investigate the long-term carcinogenic potential of MTM particulate matter (PMMTM) exposure on human bronchial epithelial cells. Our results show that chronic exposure (3 months) to noncytotoxic, physiological relevant concentration (1 mu g/mL) of PMMTM, but not control particle PMCON, induced neoplastic transformation, accelerated cell proliferation, and enhanced cell migration of the exposed lung cells. Xenograft transplantation of the PMMTM-exposed cells in mice caused no apparent tumor formation, but promoted tumor growth of human lung carcinoma H460 cells, suggesting the tumor-promoting effect of PMMTM. Chronic exposure to the main inorganic chemical constituent of PMMTM, molybdenum but not silica, similarly induced cell transformation and tumor promotion, suggesting the contribution of molybdenum, at least in part, in the PMMTM effects. These results provide new evidence for the carcinogenic potential of PMMTM and support further risk assessment and implementation of exposure control for PMMTM.
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