期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 47, 期 21, 页码 12477-12485出版社
AMER CHEMICAL SOC
DOI: 10.1021/es402764d
关键词
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资金
- NIH [P20 ES018135, R21 ES17763, R01 ES013527, R01HD31544]
- NIEHS [STAR RD83467801]
- U.S. Environmental Protection Agency [STAR RD83467801]
Bisphenol-A (BPA) is an endocrine disrupting chemical used in numerous consumer products, resulting in universal exposure in the United States. Prenatal exposure to BPA is associated with numerous reproductive and developmental effects in animals. However, little is known about human fetal exposure or metabolism of BPA during midgestation. In the present study, we present a new liquid chromatography-tandem mass spectrometry method to directly measure concentrations of BPA and two predominant metabolic conjugates-BPA glucuronide and BPA sulfate-in umbilical cord serum collected from elective second trimester pregnancy terminations. We detected at least one form of BPA in all umbilical cord serum samples: BPA (GM 0.16, range
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