期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 46, 期 15, 页码 8164-8173出版社
AMER CHEMICAL SOC
DOI: 10.1021/es3015887
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资金
- Progetto Lagrange-Fondazione CRT, Torino, Italy
- French Research Agency (ANR) through project PEPSEA
It is shown here that carbamazepine (CBZ) would undergo direct photolysis and reaction with (OH)-O-center dot as the main phototransformation pathways in surface waters. Environmental lifetimes are expected to vary from a few weeks to several months, and predictions are in good agreement with available field data. Acridine (I) and 10,11-dihydro-10,11-trans-dihydroxy-CBZ (V) are the main quantified phototransformation intermediates upon direct photolysis and (OH)-O-center dot reaction, respectively. The photochemical yield of mutagenic I from CBZ is in the 3-3.5% range, and it is similar for both direct photolysis and (OH)-O-center dot reaction: it would undergo limited variation with environmental conditions. In contrast, the yield of V would vary in the 4-8.5% range depending on the conditions, because V is formed from CBZ by (OH)-O-center dot (9.0% yield) more effectively than upon direct photolysis (1.4% yield). Other important photointermediates, mostly formed from CBZ upon (OH)-O-center dot reaction, are an aromatic-ring-dihydroxylated CBZ (VI) and N,N-bis(2-carboxyphenyl)urea (VII). Compounds VI and VII are formed by photochemistry and are not reported as human metabolites; thus, they could be used as tracers of CBZ phototransformation in surface waters. Interestingly, VI has recently been detected in river water.
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