期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 45, 期 10, 页码 4586-4593出版社
AMER CHEMICAL SOC
DOI: 10.1021/es1039979
关键词
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资金
- Health Canada [4500190296]
- NSERC
In vitro digestors can be used to provide bioaccessibility values to help assess the risk from incidental human ingestion of contaminated soils. It has been suggested that these digestors may need to include a lipid sink to mimic human uptake processes. We compare the correspondence between in vivo polycydic aromatic hydrocarbon (PAR) uptake for eight different PAH contaminated soils with PAR release in in vitro digestors in the presence and absence of a lipid sink. Lipid sinks were essential to the success of the in vitro digestors in predicting juvenile swine PAH uptake, In the presence of the lipid sink, results of the In Vitro Digestion model (IVD) closely corresponded with a slope of 0.85 (r(2) = 0.45, P < 0.07) to the in vivo results. The Relative Bioaccessibility Leaching Procedure (RBALP) results did not correspond to the in vivo study but did tightly reflect total soil PAR concentration. We conclude that the basis of this difference between digestors is that the RBALP used an aggressive extraction technique that maximized PAR release from soil. Systemic uptake in juvenile swine was not linked to soil PAH concentration but rather to the thermodynamic properties of the soil.
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