Perfluoroalkyl Contaminants in an Arctic Marine Food Web: Trophic Magnification and Wildlife Exposure

To better understand the bioaccumulation behavior of perfluoroalkyl contaminants (PFCs),we conducted a comparative analysis of PFCs and lipophilic organohalogens in a Canadian Arctic marine food web. Concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctansulfoamide (PFOSA), and C-7-C-14 perfluorocarboxylic acids (PFCAs) ranged between 0.01 and 0.1 ng.g(-1) dry wt in sediments and 0.1 and 40 ng.g(-1) wet wt in biota, which was equivalent to or higher than levels of PCBs, PBDEs, and organochlorine pesticides. In beluga whales, PFOS and PFCA concentrations were higher (P < 0.05) in protein-rich compartments (liver and blood), compared to other tissues/fluids (milk, blubber, muscle, and fetus). In the marine. mammalian food web, concentrations of PFOSA and lipophilic organochlorines (ng.g(-1) lipid equivalent) and proteinophilic substances (i.e., PFOS and C-8-C-14 PFCAs, ng.g(-1) protein) increased significantly (P < 0.05) with trophic level. Trophic magnification factors (TMFs) of organochlorines ranged between 5 and 14 and exhibited significant curvilinear relationships (P < 0.05) with octanol-water and octanol-air partition coefficients (K-OW, K-OA). TMFs of perfluorinated acids (PFAs) ranged between 2 and 11 and exhibited similar correlation (P < 0.05) with protein-water and protein-air partition coefficients (K-PW, K-PA). PFAs did not biomagnify in the aquatic piscivorous food web (TMF range: 0.3-2). This food web specific biomagnification behavior was attributed to the high aqueous solubility and low volatility of PFAs. Specifically, the anticipated phase-partitioning of these proteinophilic substances, represented by their protein-water (K-PW) and protein-air (K-PA) partition coefficients, likely results in efficient respiratory elimination in water-respiring organisms but very slow elimination and biomagnification in air-breathing animals. Lastly, the results indicate that PFOS exposure in nursing Hudson Bay beluga whale calves (Cl-95 range = 2.7 x 10(-5) to 1.8 x 10(-4) mg.kg bw(-1).d(-1)), exceeds the oral reference dose for PFOS (7.5 x 10(-5) mg.kg bw(-1).d(-1)), which raises concern for potential biological effects in these and other sensitive Arctic marine wildlife species.