期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 43, 期 22, 页码 8566-8572出版社
AMER CHEMICAL SOC
DOI: 10.1021/es901915f
关键词
-
资金
- NSERC
The exposure sources of perfluorooctane sulfonate (PFOS) in humans and wildlife are not well characterized. Human biomonitoring data show that PFOS profiles may consist of up to similar to 50% branched isomers, despite the fact that historical direct manufacturing of PFOS generally resulted in products containing no more than similar to 30% branched isomers. These observations cannot be explained based on what is known about the pharmacokinetics of branched PFOS isomers; thus, here we examined the relative isomer-specific biotransformation rates of a model PFOS-precursor (N-ethylperfluorooctane sulfonamide, NEtFOSA) with human microsomes and recombinant human cytochrome P450s (CYPs) 2C9 and 2C19. Using solid phase microextraction-gas chromatography-electron capture detection to monitor NEtFOSA disappearance, and liquid chromatography-tandem mass spectrometry to monitor product formation, we showed that in general, human microsomes and CYP isozymes transformed the branched isomers more rapidly than linear NEtFOSA, Among branched isomers, perfluoroalkyl branching geometry significantly influenced the rate of biotransformation. As a result, PFOS isomer patterns in biota exposed predominantly to precursors could be much different than expected from the isomer pattern of the precursor, While these data are suggestive that the relatively high abundance of branched PFOS isomers present in some humans, or wildlife, may be explained by substantial exposure to PFOS-precursors, in vivo studies with other relevant PFOS-precursors are warranted to validate this as a biomarker of exposure source.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据