期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 43, 期 6, 页码 2159-2165出版社
AMER CHEMICAL SOC
DOI: 10.1021/es8030402
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Chlorinated and brominated polycyclic aromatic hydrocarbons (CIPAHs and BrPAHs) occur as pollutants in the environment. Nevertheless, there is little information available regarding the toxic effects of CIPAHs and BrPAHs. The potencies of 19 individual CIPAHs and 11 individual BrPAHs to induce aryl hydrocarbon receptor (AhR)-mediated activities (i.e., dioxin-like toxicity), relative to the potency of 2,3,7,8-tetrachlorodibenzojo-dioxin (TCDO), were determined in vitro by use of a recombinant rat hepatoma cell (H411E-luc) assay. Several CIPAHs elicited AhR-mediated activity, the relative potencies (RePs) of 6-monochlorochrysene, and 7-monochlorobenz[a]anthracene were 2.6 x 10(-5) and 6.3 x 10(-6), respectively. Among BrPAHs, 7-monobromobenz[a]anthracene and 4,7-dibromobenz[a]anthracene had the highest RePs, 2.1 x 10(-5) and 2.3 x 10(-1), respectively. None of the chlorinated or brominated anthracene or fluorene compounds elicited AhR-mediated activity at the concentrations tested. We developed a structure-activity relationship for AhR-mediated potencies of CIPAHs. The RePs of ClPhe and ClFlu (lowmolecular-weight CIPAHs) were directly proportional to the compounds' degrees of chlorination. The RePs of higher-molecular-weight CIPAHs (>= 4-rings) were lower than those of the corresponding parent CIPAHs. The RePs of BrPAHs were higher than the RePs of the corresponding CIPAHs. For instance, 6-BrBaP was more potent than 6-ClBaP and 7-BrBaA was more potent than 7-ClBaA. The RePs determined in this study were applied to literature concentrations of Cl- and Br-PAHs in environmental samples, to calculate dioxin-like toxicities, as toxic equivalents (TEQs). The TEQs of CIPAHs calculated using the concentrations of individual CIPAHs were 4.6 pgTEG/g in fly ash, 0.015fg-TEO/m(3) in automobile exhaust, and 0.085 fg-TEG/m(3) in urban air. 6-ClChr accounted for 80% of the total CIPAHs-TEGs in fly ash. This is the first in vitro study to report AhR-mediated activities of Cl- and Br-PAHs relative to the activity of TCDD.
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