期刊
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
卷 35, 期 6, 页码 600-604出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10799893.2015.1030412
关键词
Extracellular signal-regulated kinase; mitogen-activated protein kinases; signaling pathway
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.
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