期刊
ACS NANO
卷 9, 期 2, 页码 1692-1698出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn5064858
关键词
diagnostic; continuous monitoring; bipolar; nanoparticle; nanomedicine
类别
资金
- NIBIB [F32EB015270]
- NIGMS [R01 GM084366]
- NINDS [R01 NS081641]
- National Institutes of Health [DP1 EB016986, R01 CA186567, R01 CA157277]
Personalized medicine could revolutionize how primary care physicians treat chronic disease and how researchers study fundamental biological questions. To realize this goal, we need to develop more robust, modular tools and imaging approaches for in vivo monitoring of analytes. In this report, we demonstrate that synthetic nanosensors can measure physiologic parameters with photoacoustic contrast, and we apply that platform to continuously track lithium levels in vivo. Photoacoustic imaging achieves imaging depths that are unattainable with fluorescence or multiphoton microscopy. We validated the photoacoustic results that illustrate the superior imaging depth and quality of photoacoustic imaging with optical measurements. This powerful combination of techniques will unlock the ability to measure analyte changes in deep tissue and will open up photoacoustic imaging as a diagnostic tool for continuous physiological tracking of a wide range of analytes.
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