期刊
JOURNAL OF RAMAN SPECTROSCOPY
卷 47, 期 1, 页码 89-109出版社
WILEY
DOI: 10.1002/jrs.4844
关键词
Raman spectroscopic identification; pathogen detection; medical diagnostic; food contamination; antibiotics; bioweapons; body fluids; host-pathogen interactions
类别
资金
- Carl Zeiss Foundation
- German Research Foundation (DFG) [FOR 1738]
- collaborative research center ChemBioSys [SFB 1127]
- Federal Ministry of Education and Research (BMBF), Germany, via the Integrated Research and Treatment Center 'Center for Sepsis Control and Care' (CSCC) [FKZ 01EO1002]
- RiMaTH [02WRS1276E]
- Fast Diagnosis [13N11350]
- Fast-TB of the Free State of Thuringia [2013FE9057]
- BioInter of the Free State of Thuringia [13022-715]
- European Union (EFRE)
A fast and reliable detection and identification of microorganisms is crucial in environmental science, for food quality as well as medical diagnosis. In these fields, all types of Raman spectroscopy are gaining more and more importance during the last years. The review provides an extensive overview of recent research, technical expertise, and scientific findings based on Raman spectroscopic detection and identification of microorganisms within the years 2010 and 2015, demonstrating the diverse capability of Raman spectroscopy as a modern analytical tool. Raman spectroscopy distinguishes itself from other currently applied techniques by its easy application at low cost, its high speed of analysis, and its broad information content on both the chemical composition and the structure of biomolecules within the microorganisms. Slight chances in the chemical composition of microorganisms can be monitored by means of Raman spectroscopy and used to differentiate genera, species, or even strains. Detection of pathogens is possible from complex matrices, such as soil, food, and body fluids. Further, spectroscopic studies of host-pathogen interactions are addressed as well as the effect of antibiotics on bacteria. Copyright (c) 2015 John Wiley & Sons, Ltd.
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