期刊
ENVIRONMENTAL POLLUTION
卷 159, 期 1, 页码 169-174出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2010.09.008
关键词
Perfluorinated compounds; Serum; Breast milk; Transplacental and lactational exposure; Daily intake; Neonate
资金
- NeoEnBiz Co.
- Hanil General Hospital
- BK-21 grants of South Korea
The levels of six perfluorocarboxylates (PFCAs), four perfloroallcylsulfonates (PFASs), and one sulfonamide were measured in paired samples of maternal serum, umbilical cord serum, and breast milk. The maternal and cord sera were strongly correlated with each other for all measured compounds (r > 0.5 and p < 0.01). Nevertheless, there was a significant difference in compound composition profile between the two sera matrices, with a more depletion of the longer chain compounds in cord serum. The transfer efficiency values from maternal to cord serum (TFCS/MS) decreased by 70% with each increasing unit of -CF2 chain within a PFCA group, and for perfluorooctanesulfonate (PFOS), by a half compared to perfluorooctanoate (PFOA). In contrast to the strong correlation in concentrations between the two sera matrices, the pattern of compounds in breast milk differed considerably with those in sera. Accordingly, compound- and matrix-specific transfer must be considered when assessing prenatal and postnatal exposure. (C) 2010 Elsevier Ltd. All rights reserved.
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