期刊
ENVIRONMENTAL POLLUTION
卷 158, 期 7, 页码 2459-2464出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2010.03.023
关键词
Water environment; ESBL; Antibiotic resistance gene; Integron; Thermotolerant coliform
资金
- National Natural Science Foundation of China [30671727]
The spreading of extended-spectrum beta-lactamases (ESBL)-producing thermotolerant coliforms (TC) in the water environment is a threat to human health but little is known about ESBL-producing TCs in the Yangtze River. We received 319 ESBL-producing stains obtained from the Chongqing basin and we investigated antibiotic susceptibility, bla gene types and the presence of integrons and gene cassettes. 16.8% of TC isolates were ESBL-producing bacteria and bla(TEM+CTx-M) was the predominant ESBL type. 65.2% of isolates contained class 1 integrons, but only 3 carried intl 2. Gene cassettes were amplified and sequenced. aadA, drfA, cmlA, sat1, aar3 and two ORF cassettes were found. In conclusion, Yangtze River is heavily polluted by ESBL-producing TC bacteria and the combined bla gene type could enhance antibiotic resistance. Class 1 integrons were widespread in ESBL-producing isolates and play an important role in multi-drug resistance. Characterization of gene cassettes could reveal the dissemination of antibiotic resistance genes. (C) 2010 Elsevier Ltd. All rights reserved.
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