期刊
ENVIRONMENTAL POLLUTION
卷 157, 期 5, 页码 1544-1553出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2009.01.011
关键词
Mytilus; Biomarkers; Lysosomal structural changes; Lysosomal membrane stability
资金
- Basque Government [VEM2003-20082-C06-01, EVK3-2000-00025]
- Consolidated Research Groups (CBET Res Grp, UPV/EHU & Basque Government)
Lysosomal responses (enlargement and membrane destabilisation) in mussel digestive cells are wellknown environmental stress biomarkers in pollution effects monitoring in marine ecosystems. Presently, in laboratory and field studies, both responses were measured separately (in terms of lysosomal volume density - Vv - and labilisation period -LP) and combined (lysosomal response index - LRI) in order to contribute to their understanding and to develop an index useful for decisions makers. LRI integrates Vv and LP, which are not necessarily dependent lysosomal responses. It is unbiased and more sensitive than Vv and LP alone and diminishes background due to confounding factors. LRI provides a simple numerical index (consensus reference = 0; critical threshold = 1) directly related to the pollution impact degree. Moreover, LRI can be represented in a way that allows the interpretation of lysosomal responses, which is useful for environmental scientists. (C) 2009 Elsevier Ltd. All rights reserved.
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