期刊
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
卷 306, 期 1, 页码 155-163出版社
SPRINGER
DOI: 10.1007/s10967-015-4081-x
关键词
Photodynamic therapy (PDT); Chlorophyll-a; Metallo-chlorophyll; Nuclear imaging; I-131
资金
- Scientific and Technological Research Council of Turkey, TUBITAK [112T565]
- Department of Scientific Projects at Ege University, Izmir, Turkey [12 NBE008]
In this study, the biological potential of a nickel chlorophyll derivative (Ni-PH-A) as a multimodal agent for tumor imaging and photodynamic therapy (PDT) was investigated. Optimum conditions of labeling with I-131 were investigated and determined as pH 10 and 1 mg amount of iodogen. Biodistribution results of I-131 labeled Ni-PH-A in female rats indicated that radiolabeled Ni-PH-A maximum uptake in the liver, spleen and ovary was observed at 30 min. Intercellular uptake and PDT efficacy of Ni-PH-A were better in MDAH-2774 (human ovarian endometrioid adenocarcinoma) than in MCF-7 (human breast adenocarcinoma) cells. Ni-PH-A might be a promising multimodal agent for lung, ovary and liver tumor imaging and PDT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据