期刊
ACS NANO
卷 9, 期 12, 页码 12264-12273出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b05542
关键词
bioinspired ion channel; pH gating; ion current rectification; single nanochannel; tunable gate location
类别
资金
- National Research Fund for Fundamental Key Projects [2011CB935700, 2013CB932802]
- National Natural Science Foundation [21501185, 21473213, 21201170, 11290163, 21421061, 91127025, 21171171]
- Chinese Academy of Sciences [KJZD-EW-M01, KJZD-EW-M03]
- 111 project
pH-activated gates intelligently govern the ion transport behaviors of a wide range of bioinspired ion channels, but the mechanisms between the gate locations and the functionalities of the ion channels remain poorly understood. Here, we construct an artificial gate-location-tunable single-nanochannel system to systematically investigate the impact of the gate location on the ion transport property of the biomimetic ion channel. The gate-location-controllable single nanochannels are prepared by asymmetrically grafting pH-responsive polymer gates on one side of single nanochannels with gradual shape transformation. Experimental ion current measurements show that the gating abilities and rectification effects of the pH-gated nanochannels can be gradually altered by precisely locating the artificial pH gates on the different sites of the channels. The experimental gate-location-dependent gating and rectification of ion current in the bioinspired ion channel system is further well confirmed by theoretical simulation. This work, as an example, provides a new avenue to optimize the smart ion transport features of diverse artificial nanogate devices via precisely locating the gates on the appropriate sites of the artificial nanochannels.
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