期刊
ENVIRONMENTAL MICROBIOLOGY
卷 14, 期 1, 页码 101-113出版社
WILEY
DOI: 10.1111/j.1462-2920.2011.02516.x
关键词
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类别
资金
- National Science Foundation [MCB-0921265]
- US Department of Energy Joint Genome Institute
- CCHF, an Energy Frontier Research Center, US Department of Energy, Office of Science, BES [DE-SC0001298]
- Office of Science at the US Department of Energy [DE-AC02-05CH11231]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0921265] Funding Source: National Science Foundation
Desulfatibacillum alkenivorans AK-01 serves as a model organism for anaerobic alkane biodegradation because of its distinctive biochemistry and metabolic versatility. The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved in alkane metabolism including substrate activation, CoA ligation, carbon-skeleton rearrangement and decarboxylation. Genomic analysis suggested a route to regenerate the fumarate needed for alkane activation via methylmalonyl-CoA and predicted the capability for syntrophic alkane metabolism, which was experimentally verified. Pathways involved in the oxidation of alkanes, alcohols, organic acids and n-saturated fatty acids coupled to sulfate reduction and the ability to grow chemolithoau-totrophically were predicted. A complement of genes for motility and oxygen detoxification suggests that D. alkenivorans may be physiologically adapted to a wide range of environmental conditions. The D. alkenivorans genome serves as a platform for further study of anaerobic, hydrocarbon-oxidizing microorganisms and their roles in bioremediation, energy recovery and global carbon cycling.
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