期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 121, 期 2, 页码 263-268出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.1205034
关键词
McCarthy scale; Mexico; neurodevelopment; organochlorines compounds; prenatal exposure; prospective cohort
资金
- National Council of Science and Technology of Mexico (CONACyT) [41708, 31034-M, 13915]
- Fogarty International Center of the National Institutes of Health of Mount Sinai School of Medicine/Queens College International Training and Research in Environmental and Occupational Health Program [D43TW00640]
- FOGARTY INTERNATIONAL CENTER [D43TW000640] Funding Source: NIH RePORTER
BACKGROUND: The results of previous studies suggest that prenatal exposure to bis[p-chlorophenyl]-1,1,1-trichloroethane (DDT) and to its main metabolite, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), impairs psychomotor development during the first year of life. However, information about the persistence of this association at later ages is limited. OBJECTIVES: We assessed the association of prenatal DDE exposure with child neurodevelopment at 42-60 months of age. METHODS: Since 2001 we have been monitoring the neurodevelopment in children who were recruited at birth into a perinatal cohort exposed to DDT, in the state of Morelos, Mexico. We report McCarthy Scales of Children's Abilities for 203 children at 42, 48, 54, and 60 months of age. Maternal DDE serum levels were available for at least one trimester of pregnancy. The Home Observation for Measurement of the Environment scale and other covariables of interest were also available. RESULTS: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively. The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages. No significant statistical interactions with sex or breastfeeding were observed. CONCLUSIONS: These findings support the hypothesis that prenatal DDE impairs early child neurodevelopment; the potential for adverse effects on development should be considered when using DDT for malaria control.
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