期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 120, 期 2, 页码 290-295出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.1103705
关键词
behavior; child; mental; phthalates; prenatal; psychomotor
资金
- National Institute of Environmental Health Sciences (NIEHS) [R01ES013543, R01ES014393, R01ES08977]
- NIEHS/U.S. Environmental Protection Agency [P50 ES09600/RD 83214101]
BACKGROUND: Research suggests that prenatal phthalate exposures affect child executive function and behavior. OBJECTIVE: We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and mental, motor, and behavioral development in children at 3 years of age. METHODS: Mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoisobutyl phthalate (MiBP), and four di-2-ethylhexyl phthalate metabolites were measured in a spot urine sample collected from 319 women during the third trimester. When children were 3 years of age, the Mental Development Index (MDI) and Psychomotor Development Index (PDI) were measured using the Bayley Scales of Infant Development II, and behavior problems were assessed by maternal report on the Child Behavior Checklist. RESULTS: Child PDI scores decreased with increasing log(e) MnBP [estimated adjusted beta-coefficient = -2.81; 95% confidence interval (CI): -4.63, -1.0] and log(e) MiBP (beta = -2.28; 95% CI: -3.90, -0.67); odds of motor delay increased significantly [per log(e) MnBP: estimated adjusted odds ratio (OR) = 1.64; 95% CI: 1.10, 2.44; per log(e) MiBP: adjusted OR =1.82; 95% CI: 1.24, 2.66]. In girls, MDI scores decreased with increasing log(e) MnBP (beta = -2.67; 95% CI: -4.70, -0.65); the child sex difference in odds of mental delay was significant (p = 0.037). The ORs for clinically withdrawn behavior were 2.23 (95% CI: 1.27, 3.92) and 1.57 (95% CI: 1.07, 2.31) per log(e) unit increase in MnBP and MBzP, respectively; for clinically internalizing behaviors, the OR was 1.43 (95% CI: 1.01, 1.90) per log(e) unit increase in MBzP. Significant child sex differences were seen in associations between MnBP and MBzP and behaviors in internalizing domains (p < 0.05). CONCLUSION: Certain prenatal phthalate exposures may decrease child mental and motor development and increase internalizing behaviors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据