期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 118, 期 2, 页码 284-290出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.0900916
关键词
administrative data; air pollution; asthma; children's health; in utero; respiratory; traffic
资金
- Health Canada
- Centre for Health and Environment Research at the University of British Columbia
- Michael Smith Foundation
BACKGROUND: There is increasing recognition of the importance of early environmental exposures in the development of childhood asthma. Outdoor air pollution is a recognized asthma trigger, but it is unclear whether exposure influences incident disease. We investigated the effect of exposure to ambient air pollution in utero and during the first year of life oil risk of subsequent asthma diagnosis in a population-based nested case-control study. METHODS: We assessed all children born in southwestern British Columbia in 1999 and 2000 (n = 37,401) for incidence of asthma diagnosis tip to 3-4 years of age using outpatient and hospitalization records. Asthma cases were age- and sex-matched to five randomly chosen controls from the eligible cohort. We estimated each individual's exposure to ambient air pollution for the gestational period and first year of life using high-resolution pollution surfaces derived from regulatory monitoring data as well as land use regression models adjusted for temporal variation. We used logistic regression analyses to estimate effects of carbon monoxide, nitric oxide, nitrogen dioxide, particulate matter <= 10 mu m and < 2.5 mu m in aerodynamic diameter (PM10 and PM2.5), ozone, sulfur dioxide, black carbon, woodsmoke, and proximity to roads and point sources on asthma diagnosis. RESULTS: A total of 3,482 children (9%) were classified as asthma cases. We observed a statistically significantly increased risk of asthma diagnosis with increased earl), life exposure to CO, NO, NO2, PM10, SO2, and black carbon and proximity to point sources. Traffic-related pollutants were associated with the highest risks: adjusted odds ratio = 1.08 (95% confidence interval, 1.04-1.12) for a 10-mu g/m(3) increase of NO, 1.12 (1.07-1.17) for a 10-mu g/m(3) increase in NO2, and 1.10 (1.06-1.13) for a 100-mu g/m(3) increase in CO. These data support the hypothesis that early childhood exposure to air pollutants plays a role in development of asthma.
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