期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 118, 期 4, 页码 579-583出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.0901077
关键词
children; metal; oxidative stress; PAH; panel study; particulate matter
BACKGROUND: Air pollution is known to contribute to respiratory and cardiovascular mortality, and morbidity. Oxidative stress has been suggested as one of the main mechanisms for these effects on health. OBJECTIVE: The aim of this study was to analyze the effects of exposure to particulate matter (PM) with aerodynamic diameters <= 10 mu m (PM10) and <= 2.5 mu M (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) on urinary malondialdehyde (MDA) levels in schoolchildren. METHODS: The study population consisted of 120 schoolchildren. The survey and measurements were conducted in four cities two in China (Ala Shan and Beijing) and two in Korea (Jeju and Seoul) between 4 and 9 June 2007. We measured daily ambient levels of PM and their metal components at the selected schools during the study period. We also measured urinary 1-hydroxypyrene (1-OHP) and 2-naphthol, to assess PAH exposure, and MDA, to assess oxidative stress. Measurements were conducted once a day for 5 consecutive days. We constructed a linear mixed model after adjusting for individual variables to estimate the effects of PM and PAH on oxidative stress. RESULTS: We found statistically significant increases in urinary MDA levels with ambient PM concentrations from the current day to the 2 previous days (p < 0.0001). Urinary 1-OHP level also showed a positive association with urinary MDA level, which was statistically significant with or without PM in the model (p < 0.05). Outdoor PM and urinary 1-OHP were synergistically associated with urinary MDA levels. Some metals bound to PM10 (aluminum, iron, strontium, magnesium, silicon, arsenic, barium, zinc, copper, and cadmium) and PM2.5 (magnesium, iron, strontium, arsenic, cadmium, zinc, aluminum, mercury, barium, and copper) also had significant associations with urinary MDA level. CONCLUSION: Exposure to PM air pollution and PAHs was associated with oxidative stress in schoolchildren.
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