期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 117, 期 12, 页码 1814-1822出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.0800120
关键词
breast cancer; cohort; environment; etiology; transdisciplinary science
资金
- Breast Cancer and the Environment Research Centers
- network of centers led by the Fox Chase Cancer Center
- Michigan State University
- University of Cincinnati
- University of California, San Francisco
- Helen Diller Family Comprehensive Cancer Center
- National Institute of Environmental Health Sciences (NIEHS) [UO1 ES/CA12770, 012771, 012800, 012801]
- National Cancer Institute (NCI)
- National Institutes of Health (NIH)
- U.S. Department of Health and Human Services
OBJECTIVES: We introduce and describe the Breast Cancer and the Environment Research Centers (BCERC), a research network with a transdisciplinary approach to elucidating the role of environmental factors in pubertal development as a window on breast cancer etiology. We describe the organization of four national centers integrated into the BCERC network. DATA SOURCES: Investigators use a common conceptual framework based on multiple levels of biologic, behavioral, and social organization across the life span. The approach connects basic biologic studies with rodent models and tissue culture systems, a coordinated multicenter epidemiologic cohort study of prepubertal girls, and the integration of community members of breast cancer a vocares as key members of the research team to comprise the network. DATA EXTRACTION: Relevant literature is reviewed that describes current knowledge across levels of organization. Individual research questions and hypotheses in BCERC are driven by gaps in our knowledge that are presented at genetic, metabolic, cellular, individual, and environmental (physical and social) levels. DATA SYNTHESIS' As data collection on the cohort, animal experiments, and analyses proceed, results will be synthesized through a transdisciplinary approach. CONCLUSION: Center investigators are addressing a large number of specific research questions related to early pubertal onset, which is an established risk factor for breast cancer. BCERC research findings aimed at the primary prevention of breast cancer will be disseminated to the scientific community and to the public by breast cancer advocates, who have been integral members of the research process from its inception.
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