期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 116, 期 10, 页码 1376-1382出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.11379
关键词
children; cord blood; endocrine disruption; environmental health; polychlorinated biphenyls; polybrominated diphenyl ethers; thyroid hormones
资金
- Johns Hopkins Bloomberg School of Public Health (JHSPH) Maryland Mothers and Babies Study
- Cigarette Restitution Fund Program Research Grant
- JHSPH Center for a Livable Future
- JHSPH Department of Epidemiology
- Heinz Family Foundation
BACKGROUND: Developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). OBJECTIVE: We investigated relationships between cord serum levels of PCBs and PBDEs and thyroid hormones measured in cord blood serum and neonatal blood spots. METHODS: We measured PCBs and PBDEs, thyrotropin (TSH), thyroxine (T-4) and free T-4 (FT4) in cord blood serum from 297 infants who were delivered at the Johns Hopkins Hospital in 2004-2005. We abstracted results of total T-4 (TT4) measured in blood spots collected in the hospital and at neonatal visits. We used delivery mode (augmented vaginal deliveries and nonelective cesarean deliveries) as a surrogate for intrapartum stress, which is known to after cord blood thyroid hormones. RESULTS: In the full study population, no compounds were associated with a change in average TSH, FT4, or TT4. BDE-100 was associated with increased odds of low cord TT4, BDE-153 with increased odds of low cord TT4 and FT4, and no compounds were associated with increased odds of high TSH. For infants born by spontaneous, vaginal, unassisted deliveries, PCBs were associated with lower cord TT4 and FT4 and lower TT4 measured in neonatal blood spots. PBDEs showed consistent but mainly nonsignificant negative associations with TT4 and FT4 measurements. CONCLUSIONS: Prenatal PCB and PBDE exposures were associated with reduced TT4 and FT4 levels among infants born by spontaneous, unassisted vaginal delivery. Intrapartum stress associated with delivery mode may mask hormonal effects of PCBs and PBDEs.
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