期刊
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
卷 37, 期 2, 页码 221-231出版社
SPRINGER
DOI: 10.1007/s10653-014-9641-4
关键词
Kidney disease; Water quality; Electrolytes; Protein denaturing; Fertilizers; Soils; Aquifers; Sri Lanka
High incidence of chronic kidney disease of unknown aetiology (CKDU) in Sri Lanka is shown to correlate with the presence of irrigation works and rivers that bring-in 'nonpoint source' fertilizer runoff from intensely agricultural regions. We review previous attempts to link CKDU with As, Cd and other standard toxins. Those studies (e.g. the WHO-sponsored study), while providing a wealth of data, are inconclusive in regard to aetiology. Here, we present new proposals based on increased ionicity of drinking water due to fertilizer runoff into the river system, redox processes in the soil and features of 'tank'-cascades and aquifers. The consequent chronic exposure to high ionicity in drinking water is proposed to debilitate the kidney via a Hofmeister-type (i.e. protein-denaturing) mechanism.
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