期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 64, 期 -, 页码 40-50出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2015.03.006
关键词
ADHD; Epigenetic; DNA methylation; Histone acetylation; MeCP2
类别
资金
- National Key Basic Research Program of China (973 Program) [2012CB525003]
- National Science Foundation of China [21477031, 31200851, 31401671]
- Program for New Century Excellent Talents in University [NCET-12-0835]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130111110024]
- Huangshan Young Scholar Fund of Hefei University of Technology [407-037030]
- National Institute on Minority Health and Health Disparities (NIMH) of the National Institutes of Health (NIH) [U54MD007584, G12MD007601]
Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders of childhood. Despite its prevalence, the critical factors involved in its development remain to be identified. It was recently suggested that epigenetic mechanisms probably contribute to the etiology of ADHD. The present study was designed to examine the associations of epigenetic markers with ADHD among Chinese Han children, aiming to establish the prediction model for this syndrome from the epigenetic perspective. We conducted a pair-matching case-control study, and the ADHD children were systematically evaluated via structured diagnostic interviews, including caregiver interviews, based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised criteria (DSM-IV-R). The expression levels of risk genes DAT1, DRD4, DRDS, as well as their promoter methylation, were determined respectively, followed by the expression profiles of histone-modifying genes p300, MYST4, HDAC1, MeCP2. The multivariate logistic regressions were performed to establish ADHD prediction models. All of the seven genes tested were identified as risk factors for ADHD. The methylation of one critical CpG site located upstream of DRD4 was shown to affect its transcription, suggesting a role in ADHD's development. Aberrant DNA methylation and histone acetylation were indicated in ADHD patients. In addition, a prediction model was established using the combination of p300, MYST4 and HDAC1, with the accuracy of 0.9338. This is, to our knowledge, the first study to clearly demonstrate the associations between epigenetic markers and ADHD, shedding light on the preliminary diagnosis and etiological studies of this widespread disorder. (C) 2015 Elsevier Ltd. All rights reserved.
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