期刊
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
卷 52, 期 1, 页码 43-49出版社
WILEY-LISS
DOI: 10.1002/em.20579
关键词
chromium; chromate; sperm whale; marine mammal; genotoxicity; cytotoxicity; lead chromate; sodium chromate
资金
- NMFS [1008-1637-00]
- Maine Center for Toxicology and Environmental Health
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES016893] Funding Source: NIH RePORTER
Hexavalent chromium is a marine pollutant of concern, both for the health of ocean ecosystems and for public health. Hexavalent chromium is known to induce genotoxicity in human and other terrestrial mammals. It is also known to be present in both water and air in the marine environment. However, currently there are limited data concerning both chromium levels and its toxicological effects in marine mammals. This study investigated the cytotoxic and genotoxic effects of soluble and particulate hexavalent chromium in sperm whale skin fibroblasts. Both forms of hexavalent chromium induced concentration-dependent increases in cytotoxicity and genotoxicity indicating that these compounds can be a health risk if the whales are exposed to them. These data support a hypothesis that chromium is a concern in the marine environment in general and for the health of sperm whales in particular. Environ. Mol. Mutagen. 52:43-49, 2011. (C) 2010 Wiley-Liss, Inc.
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