期刊
ENVIRONMENT INTERNATIONAL
卷 63, 期 -, 页码 19-25出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2013.10.016
关键词
Dietary exposure; Breast milk; Serum; 6-Hydroxy-BDE47; 6-Methoxy-BDE47
资金
- Special Coordination Funds for Promoting Science and Technology [1300001]
- Japan Science and Technology Agency
- Ministry of Health, Labour and Welfare of Japan [H21-Food-003, H24-Food-02]
- JSPS KAKENHI [24390049]
- Grants-in-Aid for Scientific Research [26340043, 23590739, 12J05348, 23510083, 24390049] Funding Source: KAKEN
This study investigated human exposure to neutral, phenolic, and methoxylated organohalogen contaminants (OHCs) in a duplicate diet study to evaluate their concentrations in breast milk and serum of Okinawan people from Japan during 2004-2009. Dietary intakes of phenolic OHCs were predominantly 2,4,6-tribromophenol (TriBP), followed by tetrabromobisphenol A (TBBPA), and 6-hydroxy-2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE47). After exposure, TriBP and TBBPA were transferred to breast milk, whereas 6-OH-BDE47 was selectively retained in serum. Despite a lower dietary exposure to pentachlorophenol and 4-hydroxy-CB187, both were retained in serum. For the methoxylated OHCs, 2,4,6-tribromoanisole (TriBA) and 6-methoxy-BDE47 were the predominant dietary contaminants, of which TriBA was present in both breast milk and serum, whereas 6-methoxy-BDE47 was selectively transferred to breast milk. These findings suggest that dietary exposure to phenolic and methoxylated OHCs may result in differential partitioning between breast milk and serum with different pharmacokinetic or exposure routes. (C) 2013 Elsevier Ltd. All rights reserved.
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