期刊
ENVIRONMENT INTERNATIONAL
卷 73, 期 -, 页码 323-333出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2014.08.014
关键词
Biomonitoring; Children; Urine; Exposure sources; Biomarker; Consumer products
资金
- DEMOCOPHES (LIFE + Programme DG Environment-Life09) [ENV/BE000410]
- COPHES (7th Framework Programme DG Research) [244237]
- Swedish National Environmental Monitoring Program, coordinated by Swedish EPA [NV-734-11/2151102]
Chemicals such as phthalates, parabens, bisphenol A (BPA) and triclosan (TCS), used in a wide variety of consumer products, are suspected endocrine disrupters although their level of toxicity is thought to be low. Combined exposure may occur through ingestion, inhalation and dermal exposure, and their toxic as well as combined effects are poorly understood. The objective of the study was to estimate the exposure to these chemicals in Swedish mothers and their children (6-11 years old) and investigate potential predictors of the exposure. Urine samples from 98 mother-child couples living in either a rural or an urban area were analyzed for the concentrations of four metabolites of di(2-ethylhexyl) phthalate (DEHP), three metabolites of di-iso-nonyl phthalate (DiNP), mono-ethyl phthalate (MEP), mono-benzyl phthalate (MBzP) and mono-n-butyl phthalate (MnBP), methylparaben (MetP), ethylparaben (EthP), propylparaben (ProP), butylparaben, benzylparaben, BPA, and TCS. Information on sociodemographics, food consumption habits and use of personal care products, obtained via a questionnaire, was used to investigate the associations between the urinary levels of chemicals and potential exposure factors. There were fairly good correlations of biomarker levels between the mothers and their children. The children had generally higher levels of phthalates (geometric mean Sigma DEHP 65.5 mu g/L; Sigma DiNP 37.8 mu g/L; MBzP 19.9 mu g/L; MnBP 76.9 mu g/L) than the mothers (Sigma DEHP 38.4 mu g/L; Sigma DiNP 33.8 mu g/L; MnBzP 12.8 mu g/L; MnBP 63.0 mu g/L). Conversely, the mother's levels of parabens (MetP 37.8 mu g/L; ProP 13.9 mu g/L) and MEP (43.4 mu g/L) were higher than the children's levels of parabens (MetP 6.8 mu g/L; ProP 2.1 mu g/L) and MEP (28.8 mu g/L). The urinary levels of low molecular weight phthalates were higher among mothers and children in the rural area (MBzP p = <0.001; MnBP p = 0.001-0.002), which is probably due to higher presence of PVC in floorings and wall coverings in this area, whereas the levels of parabens were higher among the children in the urban area (MetP p = 0.003; ProP p = 0.004) than in the rural area. The levels of high molecular weight phthalates were associated with consumption of certain foods (i.e. chocolate and ice cream) whereas the levels of parabens were associated with use of cosmetics and personal care products. (C) 2014 The Authors. Published by Elsevier Ltd.
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