期刊
ENVIRONMENT INTERNATIONAL
卷 42, 期 -, 页码 117-123出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2011.05.013
关键词
Reporter gene assay; Agonist equivalents; Antagonist equivalents; Dibutyl phthalate; ATR-EQ(20-80) range; Human risk
资金
- Major State Basic Research Development Program [2008CB418102]
- National Program in Control and Management of Polluted Water Bodies [2008ZX07101-003-006]
- Program for Postgraduates Research and Innovation in Jiangsu Province [CX10B_022Z]
- Canada Research Chair program
- Department of Biology and Chemistry
- State Key Laboratory in Marine Pollution, City University of Hong Kong
- Chinese Academy of Sciences
- King Saud University
Thyroid hormone disrupting compounds in water sources is a concern. Thyroid hormone (TH) agonist and antagonist activities of water sources from the Yangtze River, Huaihe River, Taihu Lake and ground water in the Yangtze River Delta region were evaluated by use of a TH reporter gene assay based on the green monkey kidney fibroblast (CV-1). While weak TH receptor (TR) agonist potency was observed in only one of 15 water sources, antagonist potency was present in most of the water sources. TR antagonist equivalents could be explained by the presence of dibutyl phthalate (DBP), with concentrations ranging from 2.8 x 10(1) to 1.6 x 10(3) mu g DBP /L (ATR-EQ(50)s). None of the ground waters exhibited TH agonist potencies while all of the samples from Taihu Lake displayed notable TR antagonist potencies. To identify the responsible thyroid active compounds, instrumental analysis was conducted to measure a list of potential thyroid-disrupting chemicals, including organochlorine (OC) pesticides and phthalate esters. Combining the results of the instrumental analysis with those of the bioassay, DBP was determined to account for 17% to 144% of ATR-EQ(50s) in water sources. Furthermore, ATR-EQ(20-80) ranges for TR antagonist activities indicated that samples from locations WX-1 and WX-2 posed the greatest health concern and the associated uncertainty may warrant further investigation. (C) 2011 Elsevier Ltd. All rights reserved.
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