期刊
ENVIRONMENT INTERNATIONAL
卷 35, 期 6, 页码 931-936出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2009.04.001
关键词
Ecotoxicology; Environmental fate; Environmental risk assessment; Marine; Tamiflu; Oseltamivir; Pandemic
资金
- Natural Environment Research Council [pml010003] Funding Source: researchfish
- NERC [pml010003] Funding Source: UKRI
In case of an avian-influenza-derived human flu pandemic, an inordinately high use of medicines over several weeks is predicted. in particular for the recommended influenza antiviral oseltamivir (Tamiflu). While the risk of oseltamivir to sewage works and freshwater bodies has already been assessed, the fact that a large percentage of the human population worldwide lives relatively close to the sea raises concern for its environmental compatibility in coastal marine waters. The potential risk of high oseltamivir use to the marine compartment is assessed in this publication, based on the 2003 European Community Technical Guidance Document (TGD) for risk assessment. Subchronic embryo-larval ecotoxicity tests with three marine invertebrates (Pomatoceros triqueter, Annelida; Mytilus edulis. Mollusca: Paracentrotus lividus, Echinodermata) and chronic growth inhibition tests with two different groups of marine microalgae (Isochrysis galbana, Haptophyta; Skeletonema costatum. Heterokontophyta) were performed with the active substance oseltamivir carboxylic acid to derive a dependable marine predicted no-effect concentration (PNEC). This was compared to a predicted environmental concentration (PEC) for oseltamivir in coastal waters, based on the worst-case freshwater PEC. The PEC/PNEC risk characterisation ratio for the marine compartment is well below 1, which in the terminology of the TGD signifies no immediate concern. Further, while oseltamivir may be persistent (P), it is not bioaccumulative (B) nor highly ecotoxic (T) and therefore not a PBT substance. In conclusion, even a high pandemic use of oseltamivir would not lead to a significant risk for the marine compartment, in confirmation of the risk assessment for sewage works and freshwaters. (C) 2009 Elsevier Ltd. All rights reserved.
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