期刊
ENVIRONMENT INTERNATIONAL
卷 34, 期 6, 页码 737-740出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2007.12.001
关键词
hexachlorocyclohexane; thyroid hormones; organochlorine compounds; newborns
资金
- Spanish Ministry of Health [FIS-97/1102, FIS-PI041436]
- Instituto de Salud Carlos III [C03/09, G03/176, CB06/02/0041]
- Fundacio La Caixa [97/009-00, 00/077-00]
- Generalitat de Catalunya-CIRIT [1999SGR 00241]
Objective: Thyroid hormones play an important role in human brain development, and some organochlorine compounds (OCs) act as thyroid disruptors. The objective of the present study was to evaluate the association between prenatal exposure to organochlorine compounds and thyroid function in newborns from a general population birth cohort in Menorca, with an a-priori specific focus; on beta-HCH. Methods: Levels of polychlorinated biphenyls (PCB congeners 28, 52, 101, 118, 138, 153 and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), dichlorodiphenyl dichloroethylene (p'p'-DDE) and dichlorodiphenyl trichloroethane (p'p-DDT) in cord serum, and thyrotropin (TSH) concentration in plasma three days after birth were measured in 387 newborns from Menorca. The TSH concentration was categorized (high or low), except for 27 children whose TSH levels were quantified. Results: Levels of beta-HCH and PCB-153 were positively related to TSH concentrations (gestational age-adjusted coefficient (p-value): 0.26 (p = 0.006) and 0.31 (p = 0.050), respectively). Conclusions: beta-HCH is potentially a new thyroid disrupting compound, deserving special interest in future studies given its high body burden in humans. (C) 2007 Elsevier Ltd. All rights reserved.
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