期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 54, 期 3, 页码 407-417出版社
WILEY
DOI: 10.1002/pola.27790
关键词
amphiphiles; amphiphilic conetworks; click chemistry; poly(epsilon-caprolactone); poly(ethylene glycol); ring-opening polymeriaztion; star polymers; synthesis
资金
- National Natural Science Foundation of China [81271706]
- Tianjin Research Foundation Advanced Technology Program [13JCZDJ C30700]
- Research Institute of the Ministry of Science and Technology Development Projects [2012EG150136]
- Technology Foundation for Selected Overseas Chinese Scholars, Ministry of Personnel of China
Well-defined star-shaped hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) amphiphilic conetworks (APCNs) have been synthesized via the combination of ring opening polymerization (ROP) and click chemistry. Alkyne-terminated six arm star-shaped PCL (6-s-PCLx-C CH) and azido-terminated PEG (N-3-PEG-N-3) are characterized by H-1 NMR and FT-IR. The swelling degree of the APCNs is determined both in water and organic solvent. This unique property of the conetworks is dependent on the nanophase separation of hydrophilic and hydrophobic phases. The morphology and thermal behaviors of the APCNs are investigated by SEM and DSC respectively. The biocompatibility is determined by water soluble tetrazolium salt reagents (WST-1) assay, which shows the new polymer networks had good biocompatibility. Through in vitro release of paclitaxel (PTX) and doxorubicin (DOX), the APCNs is confirmed to be promising drug depot materials for sustained hydrophobic and hydrophilic drugs. (C) 2015 Wiley Periodicals, Inc.
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