期刊
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
卷 37, 期 4, 页码 841-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2008.09.002
关键词
Insulin resistance; Muscle fat; Intramyocellular fat; Hepatic steatosis; Inflammation
资金
- National Institutes of Health [DK-381764, P01 HL-55, 782]
- Mechanisms of Hypertension and Cardiovascular Diseases [HL-007, 457]
- UAB General Clinical Research Center [M01-RR00032]
- Clinical Nutrition Research Unit [P30 DK56336]
- Diabetes Research and Training Center [P60 DK079626]
This article emphasizes intrahepatocellular and intramyocellular lipid accumulation as components of the insulin resistance syndrome. It examines the mechanisms responsible for the interrelationships among ectopic fat deposition, insulin resistance, and associated metabolic traits. These relationships are complex and vary according to diet, exercise, weight loss, and racial identity. Overall, there is a high degree of association of both intrahepatocellular and intramyocellular lipids with insulin resistance and associated cardiometabolic risk factors. It concludes that further research is necessary to determine the orchestrated roles of adipose and nonadipose tissue compartments in the regulation of insulin sensitivity, and mechanisms explaining racial differences in the insulin resistance syndrome-trait cluster.
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