期刊
ENDOCRINOLOGY
卷 150, 期 3, 页码 1108-1111出版社
ENDOCRINE SOC
DOI: 10.1210/en.2008-1596
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资金
- National Institutes of Health [DK-52798]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK052798, R01DK052798] Funding Source: NIH RePORTER
3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T-4 and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T-4 by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T-4, suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T-4. This review will discuss the latest developments on this recently discovered thyroid hormone derivative. (Endocrinology 150: 1108-1111, 2009)
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