期刊
ENDOCRINE REVIEWS
卷 35, 期 2, 页码 195-233出版社
ENDOCRINE SOC
DOI: 10.1210/er.2013-1053
关键词
-
资金
- Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health (NIH) [HD008920]
- intramural program of the National Heart,Lung, and Blood Institute, NIH
- Department of Pediatrics, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
- Endocrinology Unit, Faculty of Medicine, University of Brasilia, Brasilia, Brazil
- Graduate Program in Health Science, Medical School, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
- Coordenacao de Aper-feicoamento de Pessoal de Nivel Superior, Brazil
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil
Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They are critical regulators of the intracellular concentrations of cAMP and cGMP as well as of their signaling pathways and downstream biological effects. PDEs have been exploited pharmacologically for more than half a century, and some of the most successful drugs worldwide today affect PDE function. Recently, mutations in PDE genes have been identified as causative of certain human genetic diseases; even more recently, functional variants of PDE genes have been suggested to play a potential role in predisposition to tumors and/ or cancer, especially in cAMP-sensitive tissues. Mouse models have been developed that point to wide developmental effects of PDEs from heart function to reproduction, to tumors, and beyond. This review brings together knowledge from a variety of disciplines (biochemistry and pharmacology, oncology, endocrinology, and reproductive sciences) with emphasis on recent research on PDEs, how PDEs affect cAMP and cGMP signaling in health and disease, and what pharmacological exploitations of PDEs may be useful in modulating cyclic nucleotide signaling in a way that prevents or treats certain human diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据