期刊
ENDOCRINE RESEARCH
卷 34, 期 3, 页码 80-89出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07435800903156340
关键词
Primary Hypothyroidism; Combination Therapy; Levothyroxine Monotherapy
Objectives. To examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism. Methods. Seventy-one patients diagnosed with primary hypothyroidism were randomly allocated into two study groups: the first group received usual dose of levothyroxine and the second group received combination of levothyroxine and liothyronine for at least 4 months. The main outcomes were psychosocial problems (Goldberg's General Health Questionnaire, GHQ-28), bodyweight, heart. rate, blood Pressure, and serum lipid levels. Results. In both groups serum thyroid-stimulating hormone levels remained unchanged compared with baseline. Psychosocial scores, body weight, heart rate, blood pressure, and lipid profile in the two groups remained constant. The only exception was a small but significant reduction. in anxiety/insomnia in combined treatment group as compared with monotherapy. Conclusions. The data do not support the hypothesis that combined therapy improves the well-being and general health of Patients.
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