期刊
ENDOCRINE JOURNAL
卷 58, 期 1, 页码 1-6出版社
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.K10E-391
关键词
Rab27a; Coronin; GTPase; Endocytosis; Exocytosis
资金
- KAKENHI [19790636, 21790876]
- Suzuken Memorial Foundation
- Takeda Science Foundation
- Oita Broadcasting System Cultural Foundation
- Discretion of the President, Oita University
The output and time-course of insulin release from pancreatic beta-cells are elegantly controlled. The secretory process comprises pre-exocytotic stages, exocytosis and post-exocytotic stages. The small GTPase Rab27a is known to regulate pre-exocytotic stages that determine the size of the readily-releasable pool of insulin granules. GTP-Rab27a and its specific effectors are responsible for this process like other GTPases. Recently, we searched for Rab27a-interacting proteins and identified coronin 3. Unexpectedly, coronin 3 only bound GDP-Rab27a and this interaction regulated post-exocytotic stages via reorganization of the actin cytoskeleton. Since glucose converts Rab27a from the GTP- to GDP-bound form, we suggested that Rab27a plays a crucial role in stimulus-endocytosis coupling in pancreatic beta-cells, and that this is the key molecule for membrane recycling of insulin granules. In this review, we provide an overview of the roles of Rab27a and its GTP- and GDP-dependent effectors in the insulin secretory pathway of pancreatic beta-cells.
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