期刊
EMBO REPORTS
卷 15, 期 8, 页码 903-910出版社
WILEY-BLACKWELL
DOI: 10.15252/embr.201438450
关键词
APOBEC1; Apolipoprotein b; intestine; RBM47; RNA editing
资金
- Australian Research Council [DP130100779]
- University of Sydney
- NHMRC [1003100]
Cytidine (C) to Uridine (U) RNA editing is a post-transcriptional modification that is accomplished by the deaminase APOBEC1 and its partnership with the RNA-binding protein A1CF. We identify and characterise here a novel RNA-binding protein, RBM47, that interacts with APOBEC1 and A1CF and is expressed in tissues where C to U RNA editing occurs. RBM47 can substitute for A1CF and is necessary and sufficient for APOBEC1-mediated editing in vitro. Editing is further impaired in Rbm47-deficient mutant mice. These findings suggest that RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing.
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