期刊
EMBO REPORTS
卷 15, 期 6, 页码 642-656出版社
WILEY
DOI: 10.15252/embr.201438638
关键词
cancer; Hippo pathway; regeneration; stem cell; YAP
资金
- National institutes of Health [CA132809, EYO226116]
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription co-activators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.
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