期刊
EMBO REPORTS
卷 15, 期 3, 页码 231-243出版社
WILEY
DOI: 10.1002/embr.201338225
关键词
biogenesis; dynamics; mitophagy; ubiquitin; mitochondria
资金
- Deutsche Forschungsgemeinschaft
- European Research Council [AdG 233078]
Abstract Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and participates in maternal mtDNA inheritance. Under stress, mitochondrial dysfunction induces ubiquitin-dependent responses that involve mitochondrial proteome remodeling and culminate in organelle removal by mitophagy. In addition, many ubiquitin-dependent mechanisms have been shown to regulate innate immune responses and xenophagy. Here, we review the emerging roles of ubiquitin at mitochondria.
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