期刊
EMBO REPORTS
卷 15, 期 7, 页码 801-808出版社
WILEY-BLACKWELL
DOI: 10.15252/embr.201338317
关键词
clusterin; endocytosis; leptin; Lrp2; Stat3
资金
- National Research Foundation of Korea [NRF-2013R1A1A3010137]
- Asan Institute for Life Science [2011326]
- American Diabetes Association [7-12-BS-094]
Hypothalamic leptin signaling plays a central role in maintaining body weight homeostasis. Here, we show that clusterin/ApoJ, recently identified as an anorexigenic neuropeptide, is an important regulator in the hypothalamic leptin signaling pathway. Coadministration of clusterin potentiates the anorexigenic effect of leptin and boosts leptin-induced hypothalamic Stat3 activation. In cultured neurons, clusterin enhances receptor binding and subsequent endocytosis of leptin. These effects are mainly mediated through the LDL receptor-related protein-2 (Lrp2). Notably, inhibition of hypothalamic clusterin, Lrp2 or endocytosis abrogates anorexia and hypothalamic Stat3 activation caused by leptin. These findings propose a novel regulatory mechanism in central leptin signaling pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据