期刊
EMBO REPORTS
卷 16, 期 1, 页码 116-126出版社
WILEY
DOI: 10.15252/embr.201439403
关键词
human; multidimensional protein identification technology; quantitative proteomics; topological data analysis; yeast
资金
- Stowers Institute for Medical Research
- NIH grant [GM041628]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM041628, R37GM041628] Funding Source: NIH RePORTER
The study of conserved protein interaction networks seeks to better understand the evolution and regulation of protein interactions. Here, we present a quantitative proteomic analysis of 18 orthologous baits from three distinct chromatin-remodeling complexes in Saccharomyces cerevisiae and Homo sapiens. We demonstrate that abundance levels of orthologous proteins correlate strongly between the two organisms and both networks have highly similar topologies. We therefore used the protein abundances in one species to cross-predict missing protein abundance levels in the other species. Lastly, we identified a novel conserved low-abundance subnetwork further demonstrating the value of quantitative analysis of networks.
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